Early Detection of Thalassemia Major in Infant, Age 10 Months: Dr. Shashirekha’s Expertise with HPLC at Star Imaging

A ten-month-old baby was brought in with severe anemia, leaving the parents anxious and confused. The baby appeared unusually pale and weak, and routine treatments had not helped. While anemia in infants can sometimes result from nutritional deficiencies or infections, genetic conditions must also be considered.

At Star Imaging and Path Lab Limited, a routine investigation quickly became a crucial discovery that explained the child’s persistent anemia.

Thalassemia is a genetic blood disorder caused by mutations in the genes responsible for haemoglobin production. haemoglobin is the protein in red blood cells that carries oxygen throughout the body. When these genes are altered, the body cannot produce healthy haemoglobin efficiently, causing red blood cells to break down faster than normal. This leads to persistent anemia, weakness, and other health complications. In severe cases like Thalassemia Major, symptoms appear early in life, often requiring regular blood transfusions and ongoing medical care. Many families remain unaware of the genetic nature of the condition, which is why early detection is critical.

Dr. Shashirekha, Consultant Pathologist and Head of Department, Pathology at Star Imaging and Path Lab Limited, explains:
“Thalassemia occurs due to gene mutations affecting haemoglobin production. Since it is a genetic condition, routine treatment alone cannot resolve it. Early detection and preventive screening are extremely important. It requires repeated transfusions of stem cell therapy"

How HPLC Testing Detects Abnormal Haemoglobin

Routine blood tests can detect anemia but often cannot reveal the exact cause. High Performance Liquid Chromatography (HPLC) testing, however, analyzes different types of haemoglobin in the blood and identifies abnormal patterns, allowing doctors to detect genetic blood disorders like Thalassemia with precision.

At Star Imaging and Path Lab, the HPLC system was used for analysis, and the results were carefully reviewed by Dr. Shashirekha. The test revealed a haemoglobin pattern consistent with Thalassemia major, providing a clear explanation for the child’s severe anemia.

“HPLC allows us to accurately detect abnormal haemoglobin variants. Without this test, many cases of Thalassemia may remain undiagnosed for a long time. Early detection helps families make informed medical decisions and guides appropriate care,” says Dr. Shashirekha.

Why Early Thalassemia Screening Matters

Further evaluation revealed that the parents had never undergone Thalassemia screening. Many carriers of the gene show no symptoms and remain unaware of their status. If both parents carry the gene, there is a high risk that their child may develop Thalassemia major. Screening before marriage, during pregnancy, or in cases of unexplained anemia is crucial. Early detection allows families to plan medical care and make informed decisions.

Advanced Haemoglobin Analysis at Star Imaging and Path Lab Limited

Not all laboratories have access to advanced HPLC technology. While routine tests can indicate anemia, they cannot always identify the underlying genetic cause.

Star Imaging and Path Lab uses the HPLC system for detailed haemoglobin analysis. Combined with expert interpretation by Dr. Shashirekha, this technology ensures accurate diagnosis and effective guidance for patient care. Cases like this highlight how the right diagnostic test at the right time can make a meaningful difference for families and clinicians alike.

When to Consider HPLC Testing for Thalassemia

HPLC testing is recommended in the following situations:

• Persistent or unexplained anemia in children or adults.

• Family history of blood disorders.

• Couples planning pregnancy.

• Early signs of severe anemia in infants.

Early testing allows doctors to detect abnormal haemoglobin patterns and plan the most appropriate care, improving outcomes for children with Thalassemia.

Book HPLC Testing for Thalassemia Screening in Delhi

If you or your family members are experiencing unexplained anemia or are considering Thalassemia screening, early HPLC testing can make a significant difference.

Star Imaging and Path Lab offers advanced haemoglobin analysis with precise reporting under the guidance of Dr. Shashirekha. For families in Delhi, access to accurate and reliable thalassemia screening is the first step toward better understanding and managing genetic blood disorders.

Contact Star Imaging and Path Lab to learn more about HPLC testing and available diagnostic services.